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MLBGame PreviewsMilwaukee Brewers at St. Louis Cardinals
Milwaukee BrewersMilwaukee Brewers
@
Busch Stadium
St. Louis CardinalsSt. Louis Cardinals

Match Predictor

Pre-match Prediction
Milwaukee Brewers
@
St. Louis Cardinals
Milwaukee Brewers 50%St. Louis Cardinals 50%
Market LinesRun Line: St. Louis Cardinals -1Total: O/U 7.5
Model: Over 7.5
Model projects 8.0 total runs vs 7.5 line

Milwaukee Brewers

0022446688101012121414OVERUNDERO/U 7.5Runs ScoredRuns Allowed
All Over 7.5
56%
19/34
MLB: 48%
Starter
75%
3/4
vs STL
100%
1/1
Avg Total
9.1
MLB: 8.9
Game Starter (4) Last Starter vs STL vs STL (1)
Brandon Sproat #23 · RHP · Age 26
6.75
ERA (2026)
8.6
K/9 (2026)
4
Starts (2026)
9.0
Avg Total (2026)
Last 3:
L ARI (Apr 29): 4.1IP, 4ER, 5K
ND @DET (Apr 23): 5.1IP, 3ER, 4K
ND TOR (Apr 16): 6.2IP, 1ER, 6K
Bullpen (2026 Season)Average
ERA: 3.99MLB Avg: 3.9510 relievers
Recent: W 13-1W 6-1W 4-1L 2-3L 3-6
Lineup vs Brandon Sproat (Career)
No career matchup data — first meaningful meeting

St. Louis Cardinals

0022446688101012121414OVERUNDERO/U 7.5Runs ScoredRuns Allowed
All Over 7.5
66%
23/35
MLB: 48%
Starter
67%
4/6
vs MIL
100%
1/1
Avg Total
9.7
MLB: 8.9
Game Starter (6) Last Starter vs MIL vs MIL (1)
Andre Pallante #53 · RHP · Age 28
3.73
ERA (2026)
7.5
K/9 (2026)
6
Starts (2026)
9.3
Avg Total (2026)
Last 3:
W @PIT (Apr 29): 6.0IP, 1ER, 6K
L SEA (Apr 24): 5.1IP, 3ER, 8K
W @HOU (Apr 18): 5.0IP, 1ER, 5K
vs MIL: L (Sep 02 2024): 5.0 IP, 5 ER, 3 K
Bullpen (2026 Season)Poor
ERA: 4.67MLB Avg: 3.958 relievers
Recent: W 10-5W 7-2W 3-2L 1-4W 6-3
Lineup vs Andre Pallante (Career)
BatterPosPAAVGOPSHR
Brice Turang2B13.3850.8470
William ContrerasC13.2500.8911
Jackson ChourioCF11.6001.7270
Sal FrelickRF11.1110.4950
Garrett MitchellCF6.4000.9000
Joey OrtizSS6.2500.5000
Jake Bauers1B5.3331.2670
David Hamilton3B2.5001.0000
Gary SanchezC2.5001.0000
4 batters with no matchup history
Our Top PicksLive Odds
Top PickCardinals Moneyline (-118, MEDIUM)
Pallante's 3.73 ERA against Sproat's 6.75 ERA is not a marginal edge.
PickCardinals -1.0 Run Line (+128, MEDIUM)
This is the best number on this board.
PickOver 7.5 Runs (-125, LOW)
This is a lean, not a conviction play.

Milwaukee Brewers vs St. Louis Cardinals Game Preview

The pitching gap in this game is about as wide as you will find on any given MLB Wednesday. Andre Pallante takes the hill for the St. Louis Cardinals with a 3.73 ERA, a 3-2 record, and seven days of rest behind him. His last outing in Pittsburgh: 6 innings, 1 earned run, 6 strikeouts, zero walks. That is the command version of Pallante, the one who makes a limited lineup look overmatched. Standing across from him is Brandon Sproat of the Milwaukee Brewers, who carries a 6.75 ERA, zero wins, and 7 home runs surrendered in just 26.2 innings pitched. That works out to a 2.37 HR/9 rate, one of the worst marks in baseball right now.

Sproat's last three starts tell a familiar story: 4 earned runs in 4.1 innings against Arizona, 3 in 5.1 against Detroit, 1 in 6.2 against Toronto. The Toronto game is the outlier. He has issued 15 walks in 26.2 innings in 2026, so baserunners are a near-constant when he pitches. Busch Stadium carries a home run park factor of 0.95, a mild suppressor. But a pitcher surrendering nearly one home run per two innings does not get rescued by a 5% park adjustment, not when the Cardinals lead the NL with 44 home runs through 35 games and Jordan Walker is slashing .308/.377/.585 with a 1.212 OPS over the last seven days.

St. Louis has won seven of its last eight games and is 18-9 against right-handed starters in 2026. Pallante is a right-hander. Every split favors the home side. Milwaukee confirmed before first pitch that Christian Yelich is out with a groin injury. As the team confirmed: "Milwaukee is without outfielder Christian Yelich (groin)." Without him, the Brewers lose their top offensive weapon at exactly the wrong moment. Milwaukee arrives 8-8 on the road, riding a two-game losing streak, and having already dropped the series opener here 6-3 on Monday.

There is one legitimate wildcard in the Brewers lineup worth noting. Jackson Chourio owns a 1.727 OPS across 11 career plate appearances against Pallante and went 4-for-4 with a walk in Monday's game. That number is real. But 11 plate appearances is too small a sample to override the broader pitching mismatch, and without Yelich anchoring the lineup, Pallante has room to work around Chourio when it matters. Both bullpens are taxed heading into this Game 3 after the Tuesday rainout compressed the schedule. STL's relief corps carries a 4.67 ERA, which adds late-inning variance. The Cardinals still own this context: home field, momentum, and the clearly superior starting pitcher.

Milwaukee Brewers vs St. Louis Cardinals Key Insights

  • Brandon Sproat has surrendered 7 home runs in 26.2 innings (2.37 HR/9), one of the worst rates in baseball. Busch Stadium's HR park factor of 0.95 offers minimal protection against that contact profile.
  • St. Louis is 18-9 against right-handed starters in 2026. Sproat is a righty walking into a lineup that has consistently punished right-handed pitching all season.
  • Christian Yelich (groin) is confirmed out for Milwaukee. The Brewers' best power bat is gone, leaving a road lineup that bats .241 as a team with reduced depth behind him.
  • Pallante's most recent start was his best of 2026: 6 IP, 1 ER, 6 K, 0 BB against Pittsburgh. His command is at a season-high level entering this one.
  • Both bullpens are depleted entering Game 3 of a rain-shortened series. With STL's relief ERA at 4.67 and Milwaukee's at 3.99, the late innings carry elevated volatility regardless of who leads after six.
  • Chourio has a 1.727 OPS in 11 career PA vs. Pallante and is the one Brewer with documented success against tonight's Cardinals starter. Without Yelich protecting him in the order, Pallante can pitch around him carefully in critical spots.

Milwaukee Brewers vs St. Louis Cardinals Betting Picks

Picks made May 06, 2026 at 04:23 AM ET. Odds shown reflect current market prices.

Cardinals -1.0 Run Line (+128, MEDIUM)
Cardinals -1.0 Run Line (+128, MEDIUM): This is the best number on this board. Positive odds on a team favored on the moneyline, backed by a concrete pitching mismatch and a depleted opposing offense. If Sproat gives up two or three runs in the first few innings, which his recent form strongly suggests he will, St. Louis can carry a cushion into the middle innings and hold it through a closer. The STL bullpen's 4.67 ERA is the primary risk if the lead is narrow entering the seventh. Treat this as the primary value play, not a guarantee.
Over 7.5 Runs (-125, LOW)
Over 7.5 Runs (-125, LOW): This is a lean, not a conviction play. Sproat's 2.37 HR/9 rate creates genuine run-scoring upside for the Cardinals, and the analyst's projected flow of 8 combined runs would clear this line by one. The counterargument is real: Pallante's command profile suppresses Milwaukee's side of the total, and Busch Stadium runs slightly below neutral. This one lives or dies on how aggressively the Cardinals jump on Sproat in the early innings. Keep the unit size small and treat it as a speculative overlay on the Cardinals' offensive advantage.
Cardinals Over 7.5 Hits (-130, MEDIUM)
Cardinals Over 7.5 Hits (-130, MEDIUM): Sproat has issued 15 walks in 26.2 innings and carries a WHIP well above league average. No career matchup data exists between Cardinals hitters and Sproat, meaning no individual red flags cap what this lineup can do against him. Walker is hitting .308 with 10 home runs and a 1.212 OPS over the last seven days. Wetherholt has 7 home runs on the year. A starter with Sproat's walk and contact rates gives this offense constant traffic. Depleted bullpens also mean more late-inning at-bats, which adds to the hit-total ceiling. The support for this line is among the strongest in the card.
Brewers Under 7.5 Hits (-123, MEDIUM)
Brewers Under 7.5 Hits (-123, MEDIUM): Pallante is posting a 3.73 ERA with 26 strikeouts in 31.1 innings, and the batter-vs.-pitcher data here is pointed. William Contreras carries a 0.000 OPS in his most recent five plate appearances against Pallante (2025 data). Sal Frelick is hitting .111 with a 0.495 OPS across 11 career PA against him. Joey Ortiz posted a 0.000 OPS in his four most recent PA vs. Pallante. Add the Yelich absence, a team batting average of .241 on the road, and Busch Stadium's mild run-suppression, and Milwaukee's hit floor is lower than the market is accounting for.
SGP
SGP: Cardinals Moneyline + Over 7.5 Runs + Cardinals Over 7.5 Hits (MEDIUM): These three legs are correlated in the right direction. A Cardinals win in a higher-scoring game requires the Cardinals offense to produce. If St. Louis generates hits off Sproat, which their 18-9 record against righties and his 2.37 HR/9 rate both support, all three legs move forward simultaneously. The Cardinals ML anchors the ticket. A leaky Milwaukee bullpen late adds run volume to the total leg. The internal logic here is clean: Sproat struggles, Cardinals score, Cardinals win. Not a massive payout given the individual odds of each leg, but a well-structured same-game ticket.
YRFI (-104, LEAN)
YRFI (-104, LEAN): Sproat pitches the top of the first as the visiting starter. He has issued 15 walks in 26.2 innings this year and his last start ended with 4 earned runs in 4.1 innings against Arizona. The Cardinals' lineup, with Walker, Herrera, and Wetherholt near the top of the order, has the firepower to score quickly. Herrera went 2-for-2 with 3 RBI in Monday's series opener at this same ballpark. The YRFI is priced at -104, essentially a coin flip. Sproat's early-inning walk and contact rates tip that coin toward a first-inning run. Low-unit add only.

Key Players

Batting AverageMIL
Brice Turang
.304Batting Average
2B
Home RunsMIL
Gary Sanchez
5Home Runs
C
Runs Batted InMIL
William Contreras
23Runs Batted In
C
Earned Run AverageMIL
Jacob Misiorowski
2.84Earned Run Average
SP
WinsMIL
Aaron Ashby
5Wins
RP
StrikeoutsMIL
Jacob Misiorowski
59Strikeouts
SP
Batting AverageSTL
Jordan Walker
.308Batting Average
RF
Home RunsSTL
Jordan Walker
10Home Runs
RF
Runs Batted InSTL
Alec Burleson
28Runs Batted In
1B
Earned Run AverageSTL
Michael McGreevy
2.52Earned Run Average
SP
WinsSTL
Kyle Leahy
4Wins
SP
StrikeoutsSTL
Kyle Leahy
27Strikeouts
SP

Recent Form

Milwaukee Brewers
W13-1Arizona Diamondbacks
W6-1Washington Nationals
W4-1Washington Nationals
L3-2Washington Nationals
L6-3St. Louis Cardinals
St. Louis Cardinals
W10-5Pittsburgh Pirates
W7-2Los Angeles Dodgers
W3-2Los Angeles Dodgers
L4-1Los Angeles Dodgers
W6-3Milwaukee Brewers

Milwaukee Brewers vs St. Louis Cardinals Summary

Context lines up for St. Louis in nearly every direction. The Cardinals have the superior starter, the home field, recent momentum (seven wins in the last eight), the favorable split against right-handed pitching (18-9 on the season), and the knowledge that Yelich will not be in the opposing dugout. Pallante's zero-walk performance against Pittsburgh last week showed the version of him capable of carrying a quality start deep into the order, and a Brewers lineup batting .241 on the road without its best hitter is a manageable assignment. The primary play is Cardinals -1.0 at +128, positive odds on a team that should win this game clean if Sproat pitches anywhere near his 2026 form. Cardinals ML at -118 backs the same directional case at near-fair value.

The over 7.5 lean is the thinnest piece of this card. Pallante's command actually works against the over on Milwaukee's side, and the park suppresses scoring modestly. The case rests on Sproat's alarming home run and walk rates feeding the Cardinals' half of the ledger. If you play it, keep units small and accept that this is a low-signal bet built on one side of the total equation. The Chourio factor deserves acknowledgment: a 1.727 OPS across 11 career PA vs. Pallante is a real data point. But 11 PA is too small a sample to anchor a contrarian case, and without Yelich behind him in the lineup, Pallante can limit Chourio's damage by pitching around him carefully.

The honest caveat is the Cardinals' bullpen. A 4.67 ERA relief corps entering a depleted Game 3 setting, after a rainout scrambled both teams' scheduling, is not a comfortable situation to close out a lead. Pallante needs to give St. Louis five or six clean innings, and his recent trajectory says he can. Back the Cardinals, stay disciplined on unit size, and acknowledge that this is a daytime game with both clubs coming off night games. For the full slate, see our MLB picks today, NRFI picks, and player props.

Head-to-Head History

Season SeriesSTL leads series 1-0
DateMatchupResult
May 04, 2026MIL @ STLSTLSTL 6-3
May 05, 2026MIL @ STLMILMIL 0-0

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MLBGame PreviewsMilwaukee Brewers at St. Louis Cardinals