The Best NRFI/YRFI Bets Today (No Runs First Inning/Yes Runs First Innings) - Wednesday (9/28): Odds, Picks, and Analysis

NRFI (No Runs First Inning) bets, pronounced "ner-fee," are sweeping in popularity, offering bettors nail-biting action straight from the first pitch.

NRFI (No Runs First Inning) bets, pronounced "ner-fee," are sweeping in popularity, offering bettors nail-biting action straight from the first pitch. 

Still not sure what an NRFI is? Check out our detailed guide for the lowdown on NRFIs and how to capitalize on them.

We focus on two games for the best NRFI bets today. 

Today's Best NRFI/YRFI Bets

Cleveland Guardians vs Tampa Bay Rays

Wednesday, September 28th, 6:10 PM ET 

The Guardians and Rays square off for game two of their four-game set in Cleveland following Tampa Bay’s 6-5 victory last night in extra innings. 

Game box:

Cleveland Guardians (86-68) vs Tampa Bay Rays (85-69) 

Game Info: Wednesday, September 28, 2022, at 6:10 PM (Progressive Field) 

Starting pitchers: Triston McKenzie (11-11, 3.04 ERA) vs Tyler Glasnow (0-0)

Guardians vs Rays - Best Betting Odds: 

Moneyline: Guardians (-120 at PointsBet) vs Rays (+108 at BetRivers)

Run line: Guardians -1.5 (-215 at FanDuel) vs Rays +1.5 (+190 at BetRivers)

Total: Over 6.5 (+100 at Caesars) vs Under 6.5 (-112 at BetRivers) 

Check out our betting odds page for the best real-time best odds for MLB games.

Best NRFI/YRFI Bet Today:

Rationale: The Rays took the opener of this series with an extra-innings win on Tuesday, strengthening their position in the AL Wild Card race. The win snapped a seven-game win streak for the Guardians, who recently clinched the AL Central division title for 2022.  

Cleveland enters this contest with an Opponent Yes Run First Inning percentage at home this season (26.03 percent), which is 13th-most in MLB. Tampa Bay averages 0.55 first-inning runs per game, ninth-most in the league. Guardians starter Triston McKenzie has allowed 13 first-inning runs over 28 starts thus far (4.18 ERA). 

The wild card for this contest is Rays starter Tyler Glasnow, who’s making his first start since undergoing Tommy John surgery last August. Glasnow has surrendered 48 first-inning runs over 65 career starts (6.26), by far the most for any inning in his career. He’ll face MLB hitters for the first time in over a year tonight. 

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New York Mets vs Miami Marlins 

Wednesday, September 28th, 7:10 PM ET 

The Marlins upset the New York Mets on Tuesday night, stealing a 6-4 victory in Citi Field.

Game box:

New York Mets (97-58) vs Miami Marlins (64-90)

Game Info: Wednesday, September 28, 2022, at 7:10 PM (Citi Field)

Starting pitchers: Taijuan Walker (12-5, 3.53) vs Jesus Luzardo (3-7, 3.57)

Mets vs Marlins - Best Betting odds:  

Moneyline: Mets (-182 at BetRivers) vs Marlins (+165 at PointsBet)

Run line: Mets -1.5 (+118 at BetRivers) vs Marlins +1.5 (-130 at Caesars)

Total: Over 7.0 (+105 at Caesars) vs Under 7.0 (-110 at BetRivers)

Check out our betting odds screen to get real-time best odds for MLB games. 

Best NRFI Bet Today:

Rationale: The Marlins played spoiler in New York last night, plating two runs in the first inning and never looking back. The 6-4 loss by the Mets and Atlanta’s 8-2 win in Washington saw the Braves pull even with New York in the NL East standings. Tonight’s game borders on must-win status for the Mets.  

Scoring two in the first inning last night brought Miami’s first-inning runs-per-game average up to 0.29, now the second-lowest figure in the league, but the Marlins remain one of the lightest hitting teams in all of baseball. The -130 odds for this best NRFI bet today hold a 56.5 percent implied probability.  

The Mets rank eighth in MLB in first-inning runs-per-game this season (0.56), but they’re facing a starting pitcher, Jesus Luzardo, that’s only allowed three first-inning runs this season (1.69 ERA). 


Will you be backing our daily NRFI pick? Interested in more MLB content? Read our guide: How To Bet on Baseball, and visit our odds comparison tool to compare the latest odds.

Written by David Fernandez

David has more than 15 years of writing experience in sports and sports betting. Prior to becoming a full-time writer, he was a high school English, Creative Writing, and Journalism teacher for nearly 20 years. He holds a Master's Degree in English and Creative Writing.

David writes for a variety of publications, including Sidelines, Scorebook Live (SBLive), and Five Reasons Sports, and has previously been published in the Miami Herald and USA Today.