• Bills pass rush vs Tua’s pocket
  Buffalo generates sacks on 9.4% of opponent dropbacks, which ranks in the 94th percentile. Miami’s line has multiple injuries and Tua is Questionable with a leg issue, which could limit his movement when that rush gets home.

• Dolphins ground game is still dangerous
  Miami creates explosive runs, which are gains of 10 yards or more, on 6.6% of carries. That sits in the 94th percentile. Buffalo allows explosive runs on 6.3% of rushing plays and that ranks just 11th percentile, so the Dolphins may lean heavily on De'Von Achane and their backs.

• Bills explosive passes vs Dolphins’ modest air attack
  Buffalo produces explosive passes, which are gains of 15 yards or more, on 9.6% of attempts and that ranks 91st percentile. Miami’s own explosive pass rate is only 5.4% and sits near the bottom of the league. With Tyreek Hill on Injured Reserve, the Dolphins will likely need scheme and yards after the catch more than pure deep shots.

• Third down lean goes to Buffalo’s offense
  The Bills convert 45.7% of third downs, which ranks in the 88th percentile. Miami’s defense stops opponents on third down only 57.4% of the time, about average. If that gap holds, Buffalo can extend drives and wear down a thin Dolphins front.

• Miami still has a long yardage answer
  One bright spot for the Dolphins is third and long. They convert 32.8% of their third and 7-plus yards plays, which ranks in the 91st percentile. If Tua is healthy enough, that gives them some comeback ability against a Bills defense that is good but not elite on third down stop rate at 62.1%.

• Red zone edge tilts Bills, but not by much
  Buffalo scores touchdowns on 65.6% of its red zone trips, 78th percentile. Miami scores at a 53.8% rate, closer to average. On defense, the Dolphins allow touchdowns on 52.8% of opponent red zone trips, which actually ranks as a strength. How both teams finish inside the 20 will go a long way in deciding the final margin.

• Spread shows a big gap on paper
  The main handicap has the Bills around -9.5 at -119, with the Dolphins at +9.5 at -114. Laying almost 10 points on the road in a division game is always risky, even with Buffalo’s seven game win streak in the series. The juice on the Bills side is real, so you are paying up if you expect another lopsided result.

• Total suggests a shootout but with respect for both defenses
  The anchor total sits at 49.5, with the Over priced at -125 and the Under at -109. That tilt toward the Over hints at trust in Buffalo’s offense and Miami’s pace in the heat. At the same time, the Bills pass rush, plus injuries to Hill and several Miami linemen, can drag this into a more run heavy, under style game.

• Moneyline angle reflects Buffalo control
  On the two way Winner market, Buffalo is around -549 while Miami is +350. That is a huge tax on the favorite. If you like the Bills to win but not blow out the Dolphins, it may make more sense to explore alternate spreads or team totals, since a straight moneyline bet risks a lot to win a little.

• Quarterback passing props show different stories
  Josh Allen’s passing line is 232.5 yards, with both Over and Under in the -120 to -119 range. Tua Tagovailoa’s number sits at 219.5 yards, again with both sides around -120/-119. Buffalo’s explosive pass rate and Miami’s defensive injuries support Allen’s Over, but expected heat, a strong Bills run game, and a possible early lead could tilt him toward fewer attempts. Tua’s volatility is tied to his leg, his interception issues, and whether this becomes pass heavy catch up mode.

• Ground game props tie closely to the traits
  James Cook’s rushing total is 86.5 yards, and the Over sits near -119. De'Von Achane’s rushing line is 61.5 yards, with the Over at about -122. Both numbers are high, but they reflect Buffalo’s explosive_run_rate of 5.1% and Miami’s elite explosive_run_rate of 6.6%, plus both defenses giving up chunk runs. The risk is obvious though, since both backs are Questionable and a quick re-injury or committee usage can kill either Over.

• Receiving props highlight the new focal points
  De'Von Achane is set at 32.5 receiving yards, with Over around -119. Dalton Kincaid’s line is 41.5 yards with both sides at -119, and Jaylen Waddle sits at 59.5 yards with similar juice. With Hill out, Waddle and Achane should command targets, but all three players carry injury tags. Any receiving Over in this game needs a smaller stake and close tracking of pregame reports.

• Anytime touchdown markets carry heavy juice on stars
  De'Von Achane is around -163 to score, Josh Allen sits near -138, Jaylen Waddle around +150, Keon Coleman and Khalil Shakir around the mid +100s. Those prices fit their likely red zone roles, but Q tags on Achane and Waddle, and the physical nature of Allen’s running style, create real downside. You are paying full freight on the biggest names.

This matchup sets up as another chance for Buffalo to flex its control over Miami. The Bills come in with a strong explosive pass game, a top tier pass rush, and good third down numbers on offense. They are in a tight AFC East race and have every reason to stay focused, even as large road favorites.

The Dolphins have a path if the ground game hits. Their explosive run rate sits near the top of the league, and the Bills have had issues stopping big runs. In heat and humidity at home, that is the one clear spot where Miami can lean on talent and scheme. De'Von Achane, if he is close to full strength, is the player who can change the shape of this game.

From a betting angle, the question is whether you trust Buffalo to cover a big spread in tough conditions. Laying close to 10 points on the road in a division game always brings high variance. Injuries on both defensive fronts and in both receiver rooms add even more noise. It is easy to see a Bills blowout if Allen and Cook roll, but also easy to see a back door cover if Miami’s run game keeps them close.

No matter what you play, stay aware of the injury report, especially for Cook, Achane, Waddle, and the cluster of Bills defenders. Be honest about how much juice you want to lay on a side or a prop. This game offers clear edges on paper, but health, heat, and turnovers can flip any script fast.