
Get your popcorn ready — the Seahawks and 49ers are squaring up in a clash that could decide more than just bragging rights. Seattle heads into Levi’s Stadium as a 1.5-point road favorite, and that’s not just because of their spiffy throwback uniforms. The Niners have a glaring weakness: a struggling pass rush. Seattle's offense, brimming with size mismatches and physicality, could make this a long afternoon for San Francisco’s defense, especially if stars like Trent Williams and George Kittle aren’t suiting up.
This one comes down to which quarterback can handle the pressure — Brock Purdy or Sam Darnold, depending on injury status. Seattle’s secondary is no joke, and if Darnold’s under center, expect them to bring heat and force some turnover-worthy throws. On the flip side, the 49ers’ offense has been mixing up formations and personnel better than a Vegas card dealer. But if the run defense doesn’t stiffen up, Seattle’s ground game might run wild. The playoff seeding implications are real — the winner could host a wild card game, while the loser might be booking flights as the away team.
Dan Campbell’s Lions are limping into Chicago, where the Bears are suddenly looking feisty. The Bears are slight favorites, riding the wave of improved defensive play and Justin Fields’ late-season swagger. Meanwhile, Detroit’s defense has turned into a sieve, and their offense feels stuck in neutral. Still, don’t count them out — if they get over 100 rushing yards, they’re undefeated this year. That stat alone should have bettors circling the over in what could be a sneaky shootout.
Ben Johnson's name is floating in Coach of the Year conversations, and this game could be a resume-builder or a blemish. Chicago wants to keep its momentum going heading into the offseason, and if their defense can bottle up the Lions’ run game, they’ll have the edge. But if Jared Goff and company can find some offensive rhythm, it could be a long afternoon for the Bears' secondary. This one smells like a high-scoring, who-has-the-ball-last kind of showdown.
Put on a seatbelt if you’re watching the NFC South games this week. The Saints and Falcons are in a winner-takes-the-division grudge match, and somehow, the Bucs could still sneak in with a win over the Panthers. The Falcons are 3-point favorites, but the Saints’ offense has found some juice lately, especially when Tyler Shuck is kept clean. If the Falcons get pressure, that could flip the script. Expect a chess match between blitz-heavy looks and max protection schemes.
Meanwhile, the Buccaneers are clinging to playoff life. Baker Mayfield is clearly playing through pain, and the offense looks scrambled. But if they can get their run game going and avoid dumb penalties, they might just sneak past a Panthers team that’s been unpredictable all year. Bryce Young’s vertical passing game is the Panthers’ slim hope, but Tampa’s secondary might be too much. This game could come down to who wants it more — and who makes fewer mistakes.
The AFC slate is just as spicy. The Ravens are favored over the Steelers, even with questions swirling around Lamar Jackson’s availability. Baltimore’s offense is trending up, and Derrick Henry is doing Derrick Henry things. Meanwhile, the Steelers look lost without key offensive playmakers. If T.J. Watt is out, Baltimore should roll and lock up a higher seed.
In Houston, the Texans face the Colts in a game with massive playoff implications. Houston’s defense has been quietly dominant, and their pass rush could feast on a Colts offensive line that’s been up and down. The Colts started the season hot but have cooled off, and if their offense sputters again, the Texans could walk away with a win and a postseason ticket.
Over in Jacksonville, the Jaguars are eyeing a home playoff game if they can take care of business against the Titans. The Jags need to show they can run the ball consistently to be taken seriously as Super Bowl threats. The Titans, meanwhile, are playing for pride and building blocks. Expect Jacksonville to pull away late, but don’t be shocked if this one’s closer than expected.
Buffalo faces the Jets in what could be a sentimental farewell to Ralph Wilson Stadium. The Bills are expected to win easily, especially if they lean into their tight end trio. Josh Allen gives them a puncher’s chance in any playoff scenario, but they’ll need to clean up their run game first.
The Rams are trying to bounce back against the Cardinals. Matthew Stafford is slinging it like vintage Stafford, but the secondary has been an issue. Arizona could play spoiler, but the Rams need this one to feel good heading into the postseason.
The Raiders could blow their shot at the number one overall pick if they somehow beat the Chiefs — a classic Week 18 chaos scenario. Kansas City is favored by 5.5, but don’t be shocked if the Raiders make their fans sweat. Chris Oladokun looked decent in relief, and weird things happen when the playoffs are near.
And in case you missed it — Andy Reid is sticking around in KC, Chip Kelly is now coordinating at Northwestern, and the Bengals are crossing their fingers that Joe Burrow doesn’t end up on the wrong end of a historic sack. Again.

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The 49ers survived a thrilling 42-38 Week 17 victory over the Bears, with Brock Purdy and Christian McCaffrey leading San Francisco's offense despite missing key defenders. The Bears' near-comeback fell short on the final play, while the 49ers maintain playoff contention with upcoming challenges ahead.

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