
The Houston Texans and Los Angeles Chargers are both riding win streaks into a game that could shake up the AFC playoff picture. The key to this matchup? Pressure and protection. The Texans' defense has been cooking up some spicy blitz packages lately, ranking near the top in pressures thanks to Jesse Minter’s creative schemes. If the Chargers’ offensive line doesn't hold up — especially with Jamaree Salyer banged up — Justin Herbert could be in for a long afternoon.
On the flip side, the Texans’ secondary has shown a soft spot for big plays. That’s music to the ears of Keenan Allen and Quentin Johnston, assuming Herbert has time to throw. CJ Stroud has won four straight but has been up and down. If he plays clean football, he can keep pace. This one feels like a coin flip, but betters should keep a close eye on injury reports and lean toward the team that wins in the trenches — or at least protects their QB better.
The Jaguars and Colts are playing for drastically different futures. Jacksonville is trending up, with Trevor Lawrence looking sharp and posting a near-perfect QBR on third downs over the last three weeks. That’s not just good — that’s elite. The Colts, meanwhile, are unraveling. In their last must-win game, their defense leaked like a sieve, and Jonathan Taylor could struggle to find room against a disciplined Jags front.
The Jags are favored here for good reason. Look for them to create explosive plays, something the Colts have been vulnerable to all year. Watch out for Alec Pierce and rookie Parker Washington to make splash plays. If the Jaguars jump out early, it could be a long day for Indy. Betting-wise, Jacksonville covering the spread looks like a solid lean, especially if Taylor is bottled up early.
If you like playoff previews, this Bears-49ers matchup is your main course. DeAndre Swift and Kyle Monangai have become a two-headed bulldozer in Chicago’s backfield, running through defenses and pushing the Bears toward a possible NFC North crown. But standing in their way is a San Francisco team that’s surging at the right time.
Brock Purdy is back to making quick, smart decisions, and the 49ers passing attack looks crisper than ever. While neither defense is locked down, the Bears have a knack for late-game magic and takeaways. Still, the 49ers might have the better overall unit. Their offensive ceiling is sky-high when healthy, and they’ve got the experience to close games. This one could be a shootout, and betting the over is a strong play if both offenses click early.
With Lamar Jackson questionable and the Ravens’ playoff hopes hanging by a thread, the Steelers suddenly have a path to the division crown. Pittsburgh's second-half performances have been clutch, and their defense has found another gear. They’re favorites against a Browns team that played the Bills tough last week but still couldn’t finish the job.
Keep an eye on Myles Garrett, who’s one sack away from history. If Aaron Rodgers holds the ball too long — as he’s been doing lately — the Browns could make life difficult. But Pittsburgh has the edge in form and momentum. With John Harbaugh’s job security in question and injuries piling up, the Steelers could be the smart bet to win the game and maybe even the division.
Don’t look now, but Bryce Young is starting to figure things out. The Panthers are on a roll, and their defense — led by the disruptive Derek Brown — is a problem for anyone, especially a Seahawks team that’s been inconsistent in the trenches. Seattle's offensive line has more holes than a backyard fence, and if they can’t get the run game going, it’s going to be a long day.
While the Seahawks are the favorites, the Panthers have the momentum. The path to a Carolina win is simple: pressure the quarterback, force mistakes, and let Young cook. This game smells like an upset, so taking the Panthers with the points might be the value pick of the week.
Fantasy managers, this week is loaded with boom-or-bust potential. RJ Harvey and Ashton Gentie are emerging as must-starts down the stretch. Kenneth Gainwell has quietly become a PPR gem, averaging over six targets a game. And don’t sleep on Ramondre Stevenson if Damien Harris is out — he’s got RB1 upside written all over him.
At tight end, avoid the usual suspects like Travis Kelce and Tyler Conklin this week. Instead, consider rolling the dice on Hunter Henry or Darren Waller, especially in matchups where defenses struggle against tight ends in the red zone. And if you’re desperate at QB, Tyler Shough has shown some sneaky consistency and could be a deep-league lifesaver.

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Ravens keep failing first-half totals and collapsing at home, the Patriots keep grinding out wins while Drake May climbs MVP odds, and the AFC is a chaotic scramble with the Jags surging and the Bengals spoiling others’ runs — plenty of betting edges as the stretch run intensifies.

Week 17 NFL betting bonanza: Favorites like Cowboys, Lions, Chiefs shine; teaser gold in Bengals, Rams, Texans; overs in Jags-Colts, Bengals-Cards; Eagles, Panthers bite as dogs. 65% win rate picks to stack your bankroll!