• Protection risk for Arizona: The Cardinals have a 14.7% sack rate allowed (3rd percentile, small early sample). That stresses timing routes and pushes Murray to scramble.

• 49ers takeaways travel: San Francisco’s defense owns a 3.5% turnover generation rate (91st percentile). Short fields could follow if pressure forces mistakes.

• Explosive pass filter: Arizona’s defense allows explosive passes on just 2.1% of attempts (94th percentile). That can cap 49ers deep shots, especially with WR injuries.

• Ground game lever: Arizona’s offense hits 7.4% explosive runs (84th percentile). If the Cards crease SF’s front, they can control tempo and set up play-action.

• Third-down quality: The 49ers convert 51.9% on third down (78th percentile). That helps sustain long drives, which fits a backup-QB plan.

• Small-sample warning: These are early-season traits. Many metrics come from fewer than ~70 plays. Treat ranks as directional, not final.

• Spread: 49ers -3.0 (-118) vs Cardinals +3.0 (-119). Tight tax both ways; hooks matter in a likely one-score game.

• Total: 45.0 with Over -122 and Under -110. The juice leans to points, but injuries point to uneven offense.

• Moneyline: 49ers -152, Cardinals +130 in regulation.

• McCaffrey over 67.5 rush yds (-122): SF likely leans run with Purdy out and WR injuries.

• Trey McBride over 62.5 rec yds (-120): SF has allowed a 9.8% explosive pass rate; McBride is Murray’s high-volume target.

• Marvin Harrison Jr. over 47.5 rec yds (-122): Expect a usage bump to attack SF’s intermediate zones.

• Kyler Murray over 28.5 rush yds (-116): OL injuries plus SF pressure create scramble chances.

• Jauan Jennings over 53.5 rec yds (-120) volatility: He’s Questionable; number is live only if he suits up.

Arizona’s path is clear: protect Kyler just enough and run with efficiency. Their offense has flashed chunk gains on the ground. If that shows up, play-action can free Marvin Harrison Jr. and Trey McBride for explosive catches.

San Francisco’s path is steadier. With Purdy out, expect a controlled plan. The 49ers have been strong on third down and force turnovers at a high rate. Christian McCaffrey should be the engine behind a patient, ball-control approach.

The line at 49ers -3.0 and total 45.0 fits a tight divisional game. Field position, sacks, and red-zone trips should swing it. The matchup favors San Francisco’s structure against Arizona’s shaky protection, but Murray’s legs can flip drives on a single play.

If you play this board, price discipline matters. Several props carry real juice, which raises variance and reduces margin. Consider injury volatility on any 49ers receiver markets, and be ready to pivot if late statuses change.