NFL Week 3 Odds and Picks - Intriguing Intra-division Matchups, and a Clash of Legendary QBs, Headline Proceedings

NFL Odds for Week 3 - Recommended Bets

• Buffalo Bills @ Miami Dolphins: Bills -5.5, -107 at PointsBet
• Philadelphia Eagles @ Washington Commanders: Commanders +6.5, -107 at PointsBet
• Green Bay Packers @ Tampa Bay Buccaneers: Buccaneers -2, -110 at Caesars
• Bills to score first, -136 at FanDuel
• Eagles-Commanders to score over 5.5 total touchdowns, -105 at PointsBet
• Both teams to score 1+ touchdown in each half, +250 at FanDuel

Intra-division Games and Intriguing Matchups Characterize Week 3 in the NFL

The NFL Week 3 odds are foreshadowing some close and competitive matchups. All 16 games on the schedule opened with lines of seven points or less. Of course, the relatively small lines don’t necessarily mean that making NFL picks in Week 3 will be easy.

The Week 3 schedule features some key intra-division games, as well as other matchups with intriguing storylines. That should combine for some compelling games. It’s also an excellent reason to dive deeper into understanding some of the Week 3 NFL lines for the most exciting games on the schedule.

For more NFL content, check out our Betting Resources, we'll have the latest weekly previews and picks for the big Monday and Thursday night football games. 

NFL Week 3 Picks

Dolphins vs Bills Predictions

Buffalo Bills @ Miami Dolphins: Sunday, September 25 at 1 pm ET on CBS

The Bills have been the most impressive team in the NFL through the first two weeks of the season, with two wins, over the defending Super Bowl champion Rams and 2021’s AFC #1 seed, the Tennessee Titans, by a combined score of 72-17. Josh Allen and the offense deserve most of the credit, as Allen is averaging over 300 yards per game, Stefon Diggs has 270 receiving yards and 4 TDs, and the running back duo of Devin Singletary and James Cook is averaging nearly five yards per carry. Every bit as impressively, though, is Buffalo’s defense which has wholly locked down two quality teams while also forcing seven turnovers.

Data taken from: pro-football-reference.com (Accurate as of 09/22/22)

However, the Dolphins should not be overlooked. Miami’s own 2-0 start has come via two different types of wins. In Week 1, it was the defense that dominated, holding the Patriots to just seven points. In Week 2’s wild comeback from a 35-14 deficit to claim a 42-38 road win over the Ravens, it was QB Tua Tagovailoa, who threw for 469 yards and six touchdowns, with 361 of those yards and four of the TDs going to the dynamite wide receiver duo of Tyreek Hill and Jaylen Waddle. It was a game that may signal a turning point and a huge step forward for Miami’s young signal caller.

Data taken from: pro-football-reference.com (Accurate as of 09/22/22)

As well as the Dolphins have played thus far, the Bills are operating on another level on both sides of the ball and have dominated this matchup historically, with seven straight wins over the Dolphins and six of them by double digits. This trend is reflected in the Week 3 odds and plays into our NFL pick for Week 3, Buffalo to cover the 5.5-point spread on the road. We’re also backing the continuation of another recent trend. The Bills have scored a touchdown on their first possession of the game in Weeks 1 and 2, and will likely take an early lead in Miami.

NFL Picks Week 3: Dolphins vs Bills Predictions

• Bills -5.5, -107 at PointsBet
• Bills to score first, -136 at FanDuel

Eagles vs Commanders Predictions

Philadelphia Eagles @ Washington Commanders: Sunday, September 25 at 1 pm ET on FOX

Preseason projections about the Eagles winning the NFC East are well on their way to coming true after a 2-0 start that’s seen them survive a potential Week 1 comeback in Detroit before cruising to a comfortable 24-7 home win over the Vikings on Monday night. The defense, which gave up 35 to the Lions in Week 1, has gotten mixed reviews, but Jalen Hurts’ continued development into one of the best dual-threat quarterbacks in the league is undeniable. Hurts has averaged 9.1 yards per pass, gaining 5.3 yards per carry (on 28 carries) and scoring three touchdowns on the ground. Of course, the addition of A.J. Brown, who’s caught 15 of 21 targets, for 224 yards, has undoubtedly helped.

Data taken from: pro-football-reference.com (Accurate as of 09/22/22)

Going on the road to face the Commanders in Week 3 will be tough. Washington endured a problematic first half last week, falling behind 22-0 at halftime against the Lions, before hitting their stride in the second half. Carson Wentz ultimately threw for 337 yards, and tossed touchdown passes to three different players, to bring the final score to a much more respectable 36-27. Washington’s skill position corps, which offered little last season outside of star wideout Terry McLaurin, now looks like a deep and talented group, with Curtis Samuel healthy and rookie Jahan Dotson looking capable of doing damage right away.

The NFL odds in Week 3 are perhaps underestimating the Commanders, especially at home. Wentz has the talent around him to score points against his former team. Even if the Washington defense can’t slow down Hurts and the Eagles offense, Wentz and company won’t just go away. Our NFL picks in Week 3 include the Commanders scoring enough points to keep the game within 6.5 points, with the two teams combining for at least six touchdowns.

NFL Picks Week 3: Eagles vs Commanders Predictions

• Commanders +6.5, -107 at PointsBet
• Over 5.5 total touchdowns, -105 at PointsBet

Buccaneers vs Packers Predictions

Green Bay Packers @ Tampa Bay Buccaneers: Sunday, September 25 at 4:25 pm ET on FOX

NFL fans should embrace the possibility that this game is potentially the last meeting between Aaron Rodgers and Tom Brady. The Green Bay Packers will enter the game with a little bit of confidence after a 27-10 win over the Bears last week. However, with Davante Adams gone, Green Bay still lacks a go-to receiver (no receiver had more than three catches against the Bears) and instead had to lean on the running game, led by the running back tandem of Aaron Jones and AJ Dillon. They combined for 193 rushing yards against Chicago.

Data taken from: pro-football-reference.com (Accurate as of 09/22/22)

Brady and the Bucs have had some offensive issues during the first two weeks. Brady has completed 59% of his passes, while Tampa’s rushing attack is gaining 3.6 yards per carry. The Buccaneers will be without leading receiver Mike Evans, suspended for Week 3. On the bright side, the Tampa defense has carried the Bucs to 2-0, with 10 sacks, six takeaways, and 13 points allowed in two games.

The NFL odds in Week 3 are appropriately tight for this game. But, with the Bucs’ excellent defense playing at home for the first time this season and Green Bay’s offense not yet clicking, our NFL picks for Week 3 project Tampa to win this game by at least a field goal. At the same time, Rodgers and Brady are both simply too good and too experienced to not each lead a team to at least one touchdown in each half.

NFL Picks Week 3: Buccaneers vs Packers Predictions

• Buccaneers -2, -110 at Caesars
• Both teams to score 1+ touchdown in each half, +250 at FanDuel

NFL Odds Week 3

Conclusion

NFL Week 3 promises some highly competitive games against intra-division matchups. What do you think of our NFL week 3 predictions? If you're interested in more football content, be sure to read our guide: How To Bet on American Football, and visit our odds comparison tool to compare the latest NFL Week 3 odds.

Frequently Asked Questions (FAQs)

Which NFL teams will win in Week 3?

There is no such thing as a sure thing in the NFL. However, the Chargers, Chiefs, Vikings, and Bengals are the most likely teams to win their Week 3 game. The NFL week 3 odds for this game can be found here: https://oddsindex.com/betting-odds

What did we learn from Week 2 in the NFL?

We learned that the Colts and Bengals could be in trouble after going winless. We learned that the Bills are living up to the hype of preseason Super Bowl favorites. We learned that Dak Prescott’s injury doesn’t mean the Cowboys should be written off.

Written by Bryan Zarpentine.

Bryan has been a sports and sports betting writer for over 12 years. When he's not writing about sports, he's usually watching sports, attending sporting events, or on road trips on his way to sporting events.  

Bryan is an NCAA football and basketball specialist who gives excellent insight into MLB and the NFL worlds.