18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading involves high risk and may result in loss of your entire investment. See polymarket.us/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated derivatives exchange and clearing organization.
Start with Dallas's situation, because it is genuinely severe. Cooper Flagg is out indefinitely with a shoulder injury. Dereck Lively II is out with a foot injury. Caleb Martin, Jett Howard, Tarik Biberovic, and Santi Aldama are all ruled out as well. That is six rotation players missing at once, including the team's two most important young pieces and their primary rim anchor. Kyrie Irving is 35 years old, 19 months removed from ACL surgery, and operating under an explicit minutes cap. On the second night of a back-to-back, he opened the second quarter on the bench against Houston earlier this week. Expect similar minute management here. When Kyrie sits, the bench unit filling those gaps posted a minus-41.8 net rating during stretches when both Flagg and Irving were simultaneously off the floor in their last game. That is not a garbage-time curiosity. With Flagg gone entirely tonight, that bench unit is the functional rotation for stretches of 15 to 20 minutes.
San Antonio is without Tobias Harris and Jayden Quaintance, but the depth comparison is not close. The Spurs carry four legitimate 16-plus PPG scoring threats in Wembanyama, Castle, Harper, and Fox. Their ORTG of 106.5 through two games ranks 18th in the league, a small-sample number that reflects an offense still finding its rhythm rather than a hard ceiling. What they do have is a structural matchup advantage that is hard to paper over. Wembanyama against a Dallas front line missing both Flagg and Lively is as clean a setup as you will find on this slate. Last season, Wembanyama averaged 28.3 PPG against Dallas across three matchups. That was with a healthier Mavericks roster. Tonight's defensive setup for Dallas is materially worse.
Our blended model projects San Antonio winning 120.4 to 109.7, a 10.7-point margin sitting inside the Spurs -12.5 spread. The back-to-back factor compresses margins historically, and the Spurs' own offensive inconsistency limits their blowout ceiling. But the situational case for a larger San Antonio win is real, and the margin between covering and not covering this spread comes down to how long Kyrie Irving actually plays.
Picks made October 24, 2026 at 06:42 AM ET. Odds shown reflect current market prices.
The sharp counterargument deserves honest treatment. When Kyrie sits on this back-to-back, the Dallas bench unit holds a minus-41.8 net rating from actual current-season data. That is not modeled. It already happened this week. With Flagg gone indefinitely, those stretches are not exception scenarios anymore. They are structural features of this game. The difference between Dallas covering +12.5 and losing by 18 comes down to how many combined minutes Kyrie and the starters can hold the margin. Medium confidence means the cover is the right side of the projection, but the situational case for a San Antonio blowout is not a fringe outcome. Size accordingly.
For more picks, check out our NBA picks today and first basket picks.
San Antonio Spurs vs Dallas Mavericks predictions: Model projects 120-110 Spurs. Best bet: Mavericks +12.5 with Flagg and Lively both out tonight.