Arizona's offensive approach tends to use pace and varied formations to stress opposing defenses, which sets up an interesting test against a Chargers unit known for its coverage intelligence. The Cardinals will need to protect the ball to stay competitive, while Los Angeles looks to impose its physical brand on both lines of scrimmage. Check back the day before the game for the full preview and picks.

• How Arizona's pace-oriented offense fares against a Chargers defense that relies on preparation and coverage precision
• Whether the Cardinals can establish a run game against a Los Angeles front that has prioritized stopping the run as a defensive foundation
• Turnover margin in what projects as a game where Arizona must play clean football to compete with a more established Chargers roster