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NFLGame PreviewsMiami Dolphins at San Francisco 49ers
Sun, Sep 20, 4:25 PM ET
@
Levi’s Stadium

The Call

Win probability, price movement and our picks · MIA @ SF
Win probability lands with picks the day before kickoff; live market pricing follows once books post prices.
Picks drop the day before kickoff
The model runs after final injury reports. Until then the story below is the substance, and it updates daily.

The Wire

MIA @ SF · odds in decimal
LIVE
Nothing on the wire for this game yet. Line moves, picks and scores land here.

Miami Dolphins vs San Francisco 49ers Game Preview

Miami travels to Levi's Stadium for a cross-conference matchup against San Francisco, a game between two franchises that have each built identities around explosive, well-designed offensive systems. The 49ers' home environment and organizational depth have made them difficult to beat at Levi's, and no trait percentile data for either team is yet available in the 2026 season to give a clearer current read.

The Dolphins have built their offense around speed and space creation, while San Francisco has leaned on a physical run-first system with play-action layered on top. That stylistic contrast, speed vs. physicality, is the central tension to track. Check back the day before the game for the full preview and picks.

Miami Dolphins vs San Francisco 49ers Key Insights

  • Whether Miami's speed-based offense can generate chunk plays against a San Francisco defense built to funnel everything underneath
  • San Francisco's run game against a Dolphins front, if they establish the ground game, the play-action passing opens up significantly
  • Situational football: third-down conversion rates will likely separate these teams in a close game

Key Players

Passing YardsMIA
Malik Willis
220YDS
15/27, 1 INTQB
Rushing YardsMIA
Malik Willis
39YDS
6 CAR, 1 TDQB
Receiving YardsMIA
Caleb Douglas
94YDS
5 RECWR
TacklesMIA
Jacob Rodriguez
14TOT
LB
Passing YardsSF
Brock Purdy
205YDS
25/34, 3 TD, 1 INTQB
Rushing YardsSF
Christian McCaffrey
68YDS
10 CARRB
Receiving YardsSF
Demarcus Robinson
50YDS
2 REC, 1 TDWR
TacklesSF
Fred Warner
11TOT
LB

Recent Form2025 season

Miami Dolphins
L38-10New England Patriots
L20-7Washington Commanders
L26-3New York Giants
L17-12Atlanta Falcons
L27-13Las Vegas Raiders
San Francisco 49ers
L41-6Seattle Seahawks
L19-13Tennessee Titans
W41-17Los Angeles Chargers
W18-12Las Vegas Raiders
W27-7Los Angeles Rams

Early look at Miami Dolphins vs San Francisco 49ers. Full preview and picks land the day before the game.

Frequently Asked Questions

NFLGame PreviewsMiami Dolphins at San Francisco 49ers