Game Preview of San Francisco 49ers @ Indianapolis Colts. Week 16 of 2025 NFL Season
| Date | Opponent | Result | ATS | O/U |
|---|---|---|---|---|
| 2025-12-14 | @ SEA | L 16-18 | L 13.5 | u41.5 |
| 2025-12-07 | @ JAX | L 19-36 | L -2.5 | o44.5 |
| 2025-11-30 | vs HOU | L 16-20 | L 3.0 | u44.5 |
| 2025-11-23 | @ KC | L 20-23 | L 3.5 | u50.5 |
| 2025-11-09 | vs ATL | W 31-25 | W +6.5 | o48.5 |
| 2025-11-02 | @ PIT | L 20-27 | L -3.5 | u51.5 |
| 2025-10-26 | vs TEN | W 38-14 | W +15.5 | o47.5 |
| 2025-10-19 | @ LAC | W 38-24 | W +2.5 | o48.5 |
| 2025-10-12 | vs ARI | W 31-27 | W +8.5 | o46.5 |
| 2025-10-05 | vs LV | W 40-6 | W +7.0 | u46.5 |
| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Total Points | 341 | #1 | 261 | #16 | |
| Total Points Per Game | 31 | #1 | 21.8 | #11 | |
| Total Touchdowns | 39 | #2 | 31 | #22 | |
| Passing Touchdowns | 17 | #16 | 22 | #27 | |
| Rushing Touchdowns | 22 | #1 | 8 | #7 | |
| Other Touchdowns | 0 | #20 | 1 | #23 | |
| Total Kicking Points | 97 | #5 | 73 | #24 | |
| Total Two Point Conversions | 2 | #4 | 0 | #30 | |
| Kick Extra Points | 31 | #7 | 25 | #13 |
| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Net Passing Yards | 2697 | #7 | 2901 | #1 | |
| Net Passing Yards Per Game | 245 | #7 | 242 | #7 | 🏈 |
| Passer Rating | 100 | #9 | 102 | #8 | |
| Passing Attempts | 355 | #20 | 425 | #31 | |
| Completions | 243 | #12 | 295 | #1 | |
| Completion Percentage | 68.5 | #7 | 69.4 | #29 | |
| Passing 1st downs | 137 | #7 | 144 | #30 | |
| Passing 1st Down % | 55.5 | #18 | 59.3 | #28 | |
| Longest Pass | 75 | #7 | 50 | #27 | |
| Passing Fumbles Lost | 4 | #5 | 5 | #4 | |
| Receiving Targets | 345 | #18 | 412 | #1 | |
| Receptions | 243 | #12 | 295 | #32 | |
| Receiving Yards After Catch | 1277 | #13 | 1299 | #25 | |
| YAC Average | 5.3 | #11 | 4.4 | #3 |
| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Rushing Yards | 1527 | #4 | 1211 | #15 | |
| Rushing Yards Per Game | 139 | #4 | 101 | #23 | |
| Rushing Attempts | 293 | #17 | 292 | #16 | |
| Yards Per Rush Attempt | 5.2 | #1 | 4.1 | #20 | |
| Rushing 1st downs | 91 | #4 | 77 | #18 | |
| 20+ Yard Rushing Plays | 10 | #6 | 4 | #23 | |
| Long Rushing | 83 | #1 | 48 | #20 | |
| Rushing Fumbles | 10 | #6 | 4 | #23 | |
| Rushing Fumbles Lost | 0 | #30 | 1 | #18 |