NFLGame PreviewsSF VS IND Preview Week16 22-DEC-2025

Game Preview of San Francisco 49ers @ Indianapolis Colts. Week 16 of 2025 NFL Season

SF logo

SF

10-4-0
@
23DEC25
08:15pm
IND logo

IND

8-6-0
Lucas Oil Stadium

Game Preview

<Game Preview Will Appear Soon>

Current Season Form

SF logo

SF

Away
Record:10-4-0
ATS:9-5-0
O/U:8-6-0
IND logo

IND

Home
Record:8-6-0
ATS:8-6-0
O/U:7-7-0

Head-to-Head Summary

Record:
0-5Winner logo
ATS:1-4-0
O/U:2-3-0

Past Results

DateOpponentResultATSO/U
2025-12-14@ SEAL 16-18L 13.5u41.5
2025-12-07@ JAXL 19-36L -2.5o44.5
2025-11-30vs HOUL 16-20L 3.0u44.5
2025-11-23@ KCL 20-23L 3.5u50.5
2025-11-09vs ATLW 31-25W +6.5o48.5
2025-11-02@ PITL 20-27L -3.5u51.5
2025-10-26vs TENW 38-14W +15.5o47.5
2025-10-19@ LACW 38-24W +2.5o48.5
2025-10-12vs ARIW 31-27W +8.5o46.5
2025-10-05vs LVW 40-6W +7.0u46.5

Key Insights

<Key Insights Will Appear Soon>

Betting Insights

<Betting Insights Will Appear Soon>

Final Summary

<The Game Preview Will Appear Soon>

Statistical Battle Boards

Viewing: IND Offense vs SF Defense
Offense team logoOffense
Defense team logoDefense
StatisticOffenseRankDefenseRankAdvantage
Total Points341#1261#16IND advantage
Total Points Per Game31#121.8#11IND advantage
Total Touchdowns39#231#22IND advantage
Passing Touchdowns17#1622#27IND advantage
Rushing Touchdowns22#18#7IND advantage
Other Touchdowns0#201#23IND advantage
Total Kicking Points97#573#24IND advantage
Total Two Point Conversions2#40#30IND advantage
Kick Extra Points31#725#13IND advantage
Offense team logoOffense
Defense team logoDefense
StatisticOffenseRankDefenseRankAdvantage
Net Passing Yards2697#72901#1SF advantage
Net Passing Yards Per Game245#7242#7🏈
Passer Rating100#9102#8SF advantage
Passing Attempts355#20425#31IND advantage
Completions243#12295#1SF advantage
Completion Percentage68.5#769.4#29IND advantage
Passing 1st downs137#7144#30IND advantage
Passing 1st Down %55.5#1859.3#28IND advantage
Longest Pass75#750#27IND advantage
Passing Fumbles Lost4#55#4SF advantage
Receiving Targets345#18412#1SF advantage
Receptions243#12295#32IND advantage
Receiving Yards After Catch1277#131299#25IND advantage
YAC Average5.3#114.4#3SF advantage
Offense team logoOffense
Defense team logoDefense
StatisticOffenseRankDefenseRankAdvantage
Rushing Yards1527#41211#15IND advantage
Rushing Yards Per Game139#4101#23IND advantage
Rushing Attempts293#17292#16SF advantage
Yards Per Rush Attempt5.2#14.1#20IND advantage
Rushing 1st downs91#477#18IND advantage
20+ Yard Rushing Plays10#64#23IND advantage
Long Rushing83#148#20IND advantage
Rushing Fumbles10#64#23IND advantage
Rushing Fumbles Lost0#301#18SF advantage