Game Preview of Tennessee Titans @ Arizona Cardinals. Week 5 of 2025 NFL Season
The Tennessee Titans head west to face the Arizona Cardinals on Sunday at State Farm Stadium. Kickoff is set for 1:00 PM ET in Week 5. Arizona comes in at 2-2 while Tennessee remains winless at 0-4.
The Titans’ season has unraveled quickly. Rookie quarterback Cam Ward has been sacked 17 times and now faces a Cardinals defense that ranks top 10 in stopping third downs. Head coach Brian Callahan is already under heavy fire, with speculation swirling around his job security.
Arizona has its own concerns. The Cardinals are down to backup backs Michael Carter and Emari Demercado after losing James Conner and Trey Benson. That shifts even more weight to Kyler Murray and rookie wideout Marvin Harrison Jr., who flashed with a touchdown last week against Seattle.
Oddsmakers have Arizona as a strong favourite. The line sits at Cardinals -7.5 (-110) with a game total of 41.5. Tennessee hasn’t scored more than 16 points in a game this season, while Arizona has kept all four contests within one score.
| Date | Opponent | Result | ATS | O/U |
|---|---|---|---|---|
| 2025-09-25 | vs SEA | L 20-23 | L -1.5 | u43.5 |
| 2025-09-21 | @ SF | L 15-16 | L 1.5 | u44.5 |
| 2025-09-14 | vs CAR | W 27-22 | W +7.0 | o45.5 |
| 2025-09-07 | @ NO | W 20-13 | W +-6.0 | u44.5 |
| 2025-01-05 | vs SF | W 47-24 | W +4.5 | o42.5 |
| 2024-12-28 | @ LAR | L 9-13 | L 6.5 | u48.0 |
| 2024-12-22 | @ CAR | L 30-36 | L -5.5 | o47.0 |
| 2024-12-15 | vs NE | W 30-17 | W +6.0 | o46.5 |
| 2024-12-08 | vs SEA | L 18-30 | L 3.0 | o45.5 |
| 2024-12-01 | @ MIN | L 22-23 | L 3.5 | u45.5 |
The Titans’ offensive line has allowed sacks on 10.7% of dropbacks, putting Cam Ward under constant pressure.
Arizona’s third-down defense is strong (65.4% stop rate), while Tennessee converts just 29.6% on offense.
Calvin Ridley is questionable with a leg injury; without him, Tennessee loses its top explosive-pass option.
Arizona’s rushing attack is depleted, forcing more volume onto Kyler Murray and his receivers.
Marvin Harrison Jr. faces a Titans secondary ranked 28th against the pass and coming off back-to-back poor outings.
Tennessee’s defense has allowed explosive passes at a 6.5% clip, creating a chance for Harrison or Trey McBride to hit big plays.
Spread: Cardinals -7.5 (-110). Arizona is 2-2 but has kept games close; Titans have lost 10 straight overall.
Total: Under 41.5 (-114). Tennessee averages 10.25 points per game; Arizona leans pass-heavy without a run game.
Marvin Harrison Jr. Anytime TD +168. Usage rising; Titans have surrendered six pass touchdowns.
Kyler Murray Anytime TD +188. Mobile QB with added red-zone chances given RB injuries.
Michael Carter Over 49.5 Rushing Yards (-122). Projects as RB1 in depleted backfield.
Chig Okonkwo Over 29.5 Receiving Yards (-118). Titans TE likely to get short-yardage targets when Ward faces pressure.
This matchup is about two teams trending in different ways. The Titans are searching for answers with a rookie quarterback and a coach on the hot seat. Injuries to Calvin Ridley and multiple linemen only raise more questions about whether Tennessee can score enough to stay competitive.
Arizona has been inconsistent but resilient. Every game has been close, and Kyler Murray has leaned on his mobility to keep drives alive. Rookie Marvin Harrison Jr. is finding his stride, and he could see a heavy workload with the run game decimated.
The betting market shows little faith in Tennessee. Arizona is favoured by more than a touchdown, and the total remains low at 41.5. The under fits recent form, with both teams struggling to finish drives.
Expect Arizona to push the ball through the air and Tennessee to lean on quick throws to survive pressure. If Murray and Harrison connect early, the Cardinals could control the game. If the Titans’ defense can steal a turnover, they may at least keep it within the number.
| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Total Points | 82 | #22 | 120 | #5 | |
| Total Points Per Game | 20.5 | #22 | 30 | #29 | |
| Total Touchdowns | 8 | #23 | 13 | #27 | |
| Passing Touchdowns | 6 | #15 | 6 | #18 | |
| Rushing Touchdowns | 1 | #29 | 7 | #31 | |
| Other Touchdowns | 1 | #7 | 0 | #2 | |
| Total Kicking Points | 32 | #14 | 36 | #8 | |
| Total Two Point Conversions | 0 | #21 | 0 | #26 | |
| Kick Extra Points | 8 | #19 | 12 | #7 |
| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Net Passing Yards | 659 | #28 | 908 | #11 | |
| Net Passing Yards Per Game | 165 | #28 | 227 | #11 | |
| Passer Rating | 87.4 | #22 | 97.2 | #10 | |
| Passing Attempts | 130 | #15 | 126 | #16 | |
| Completions | 87 | #13 | 88 | #12 | |
| Completion Percentage | 66.9 | #15 | 69.8 | #27 | |
| Passing 1st downs | 42 | #19 | 40 | #11 | |
| Passing 1st Down % | 60.9 | #4 | 47.6 | #5 | |
| Longest Pass | 45 | #24 | 40 | #26 | |
| Passing Fumbles Lost | 0 | #26 | 1 | #11 | |
| Receiving Targets | 128 | #14 | 122 | #17 | |
| Receptions | 87 | #13 | 88 | #21 | |
| Receiving Yards After Catch | 430 | #16 | 455 | #22 | |
| YAC Average | 4.9 | #16 | 5.2 | #21 |
| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Rushing Yards | 423 | #22 | 566 | #28 | |
| Rushing Yards Per Game | 106 | #22 | 142 | #5 | |
| Rushing Attempts | 94 | #26 | 118 | #25 | |
| Yards Per Rush Attempt | 4.5 | #12 | 4.8 | #8 | |
| Rushing 1st downs | 19 | #30 | 32 | #26 | |
| 20+ Yard Rushing Plays | 4 | #4 | 3 | #10 | |
| Long Rushing | 52 | #8 | 50 | #9 | |
| Rushing Fumbles | 4 | #4 | 3 | #10 | |
| Rushing Fumbles Lost | 0 | #18 | 0 | #24 |