• The Titans’ offensive line has allowed sacks on 10.7% of dropbacks, putting Cam Ward under constant pressure.

• Arizona’s third-down defense is strong (65.4% stop rate), while Tennessee converts just 29.6% on offense.

• Calvin Ridley is questionable with a leg injury; without him, Tennessee loses its top explosive-pass option.

• Arizona’s rushing attack is depleted, forcing more volume onto Kyler Murray and his receivers.

• Marvin Harrison Jr. faces a Titans secondary ranked 28th against the pass and coming off back-to-back poor outings.

• Tennessee’s defense has allowed explosive passes at a 6.5% clip, creating a chance for Harrison or Trey McBride to hit big plays.

• Spread: Cardinals -7.5 (-110). Arizona is 2-2 but has kept games close; Titans have lost 10 straight overall.

• Total: Under 41.5 (-114). Tennessee averages 10.25 points per game; Arizona leans pass-heavy without a run game.

• Marvin Harrison Jr. Anytime TD +168. Usage rising; Titans have surrendered six pass touchdowns.

• Kyler Murray Anytime TD +188. Mobile QB with added red-zone chances given RB injuries.

• Michael Carter Over 49.5 Rushing Yards (-122). Projects as RB1 in depleted backfield.

• Chig Okonkwo Over 29.5 Receiving Yards (-118). Titans TE likely to get short-yardage targets when Ward faces pressure.

This matchup is about two teams trending in different ways. The Titans are searching for answers with a rookie quarterback and a coach on the hot seat. Injuries to Calvin Ridley and multiple linemen only raise more questions about whether Tennessee can score enough to stay competitive.

Arizona has been inconsistent but resilient. Every game has been close, and Kyler Murray has leaned on his mobility to keep drives alive. Rookie Marvin Harrison Jr. is finding his stride, and he could see a heavy workload with the run game decimated.

The betting market shows little faith in Tennessee. Arizona is favoured by more than a touchdown, and the total remains low at 41.5. The under fits recent form, with both teams struggling to finish drives.

Expect Arizona to push the ball through the air and Tennessee to lean on quick throws to survive pressure. If Murray and Harrison connect early, the Cardinals could control the game. If the Titans’ defense can steal a turnover, they may at least keep it within the number.