We're having some technical issues.
Please come back later to see the best odds for today's games here.
Please come back later to see the best odds for today's games here.
The Call
Win probability lands with picks the day before kickoff; live market pricing follows once books post prices.
Picks drop the day before kickoff
The model runs after final injury reports. Until then the story below is the substance, and it updates daily.
The Wire
ARI @ SF · odds in decimalNothing on the wire for this game yet. Line moves, picks and scores land here.
Arizona Cardinals vs San Francisco 49ers Game Preview
San Francisco's offense is operating at an exceptional level across nearly every metric: 100th percentile in early-down success, 88th in explosive passing, 75th in explosive runs, 97th in redzone touchdown rate, and 94th in both third-down conversion and points per drive. Arizona's offense scores at only the 28th percentile per drive and generates explosive pass plays at just the 6th percentile.
Arizona's defense creates turnovers at a solid rate (75th percentile), offering a path to short fields. The structural advantage San Francisco holds across all offensive categories is among the widest team-vs-team gaps on the week's schedule.
Check back the day before the game for the full preview and picks.
Arizona Cardinals vs San Francisco 49ers Key Insights
- Arizona's turnover-forcing defense (75th pctl) and whether it can create enough short fields to remain competitive against San Francisco's complete offense
- San Francisco's passing attack (88th pctl explosive, 94th pctl third-down) against an Arizona secondary defending a near-absent explosive passing game (6th pctl) of its own
- Redzone efficiency gap: San Francisco converts at the 97th percentile, Arizona at the 37th, finishing drives will dictate the margin
Key Players
Passing YardsARI
Jacoby Brissett
372YDS
44/65, 2 TD, 1 INTQB
Rushing YardsARI
Tyler Allgeier
71YDS
22 CARRB
Receiving YardsARI
Trey McBride
136YDS
17 REC, 2 TDTE
SacksARI
Budda Baker
1.5SACKS
S
TacklesARI
Budda Baker
16TOT
S
Passing YardsSF
Brock Purdy
492YDS
45/56, 5 TD, 1 INTQB
Rushing YardsSF
Christian McCaffrey
91YDS
20 CAR, 2 TDRB
Receiving YardsSF
Mike Evans
103YDS
9 REC, 1 TDWR
SacksSF
Keion White
1SACKS
DE
TacklesSF
Ji'Ayir Brown
18TOT
S
Recent Form2025 season
Arizona Cardinals
W27-14Las Vegas Raiders
L34-13Dallas Cowboys
L42-38Green Bay Packers
W26-14Los Angeles Chargers
L31-7Seattle Seahawks
San Francisco 49ers
L19-13Tennessee Titans
W41-17Los Angeles Chargers
W18-12Las Vegas Raiders
W27-7Los Angeles Rams
W35-13Miami Dolphins
Early look at Arizona Cardinals vs San Francisco 49ers. Full preview and picks land the day before the game.
Frequently Asked Questions
