• Cincinnati ranks No. 1 in big play touchdown rate (36.2%), while Arizona sits in the bottom 3% in preventing those plays.
• The Bengals convert on third-and-long 30.9% of the time (91st percentile), a tough matchup for a Cardinals defense that struggles in short-yardage stops.
• Arizona runs no-huddle at an 81st percentile rate, which could wear down a Bengals defense ranked 3rd percentile in third-down stop rate.
• Arizona allows explosive runs at a bottom-6% rate, which may open up rushing lanes for Cincinnati’s backfield.
• Cincinnati operates out of shotgun nearly 66% of the time (97th percentile), giving Burrow more pre-snap reads against a depleted Cardinals secondary.
• The Cardinals are efficient on long drives (84.8%) and may benefit if Bengals pass rushers B.J. Hill and Joseph Ossai miss the game.

• The Bengals are -7.0 favorites (-114), reflecting Arizona’s injury concerns and Cincinnati’s offensive edge.
• The total is 52.5 points, with the Over priced at -122, books expect a fast-paced, high-scoring game.
• Joe Burrow Over 270.5 passing yards is -120, with Arizona likely missing three starting cornerbacks.
• Trey McBride Over 71.5 receiving yards is -118; he’s a top target and faces a Bengals defense lacking tight end coverage strength.
• Chase Brown Anytime TD is -175, he’s the short-yardage option in a game with a high total.

On the flip side, Jacoby Brissett could find success too. The Bengals don’t get many stops on third down and could struggle if Brissett leans on McBride and quick throws. If the Bengals’ defensive line is shorthanded, that only helps Arizona’s efficiency.

With both teams playing loose and fast, the Over 52.5 (-122) is worth a look, despite the juice. And if Marvin Harrison Jr. is out or limited, Michael Wilson props become more attractive.

Cincinnati’s offensive firepower gives them the edge. But in a meaningless game with shaky defenses, don’t rule out fireworks from both sides.