• The Eagles score touchdowns on 69.4% of red-zone trips, one of the best rates in the league.
• Buffalo’s defense allows red-zone touchdowns on 58.5% of drives, a below-average mark.
• Philly’s defense holds quarterbacks to a 74 passer rating and gives up just 19 points per game.
• Buffalo thrives on big plays, with a 9.5% explosive pass rate (92nd percentile).
• The Eagles allow 4.7% explosive runs (25th percentile), a potential weak spot for James Cook.
• Several key Bills defenders are Questionable, including safety Jordan Poyer and corner Taron Johnson, which could affect their ability to cover Philly’s receivers.

• The total sits at 43.5, with the Over juiced to -119. The Under is available at -102.
• Bills are favored by about 1.5 points in most markets, with moneyline odds around -118.
• Jalen Hurts Over 30.5 rushing yards prop is -116. He ran for 40 yards last week and may need to scramble again.
• James Cook Under 85.5 rushing yards is priced at -120. He faces one of the NFL’s best run defenses.
• DeVonta Smith Over 49.5 receiving yards is -119. He could see more targets if A.J. Brown is limited.
• Dallas Goedert Over 34.5 receiving yards is -118. Buffalo has struggled to contain tight ends.
• Hurts is -110 to score a touchdown anytime, a solid price for a mobile QB with red-zone usage.

Buffalo may need Allen to bounce back through the air, but Philly’s defense is no easy task. If the Bills can't get chunk plays, they'll have to grind it out. The Eagles, meanwhile, will look to stay balanced with Hurts leading both the passing and running games. Injuries on both sides, especially to stars like A.J. Brown and Josh Allen, could swing this game late, so it’s worth keeping an eye on final reports.

With the spread under a field goal and the total in the low 40s, oddsmakers expect a close, low- to mid-scoring battle. Bettors should factor in weather, injury updates, and motivation on both sides before locking in positions.