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TB
SF
Game Preview
The San Francisco 49ers visit the Tampa Bay Buccaneers on Sunday at 1:00 PM ET at Raymond James Stadium. Both teams are 4-1 and beat up, but they score and move the ball in different ways. Tampa leans into chunk passes. San Francisco wins on third down and with clean pockets.
Quarterback health looms over this matchup. Mac Jones is listed as questionable for the 49ers. Baker Mayfield is also questionable for Tampa Bay. That adds variance for any yardage or touchdown markets. If both go, the traits point to passing efficiency.
Tampa’s passing game has real juice even with Mike Evans out. The Bucs rank well above average in explosive pass rate and scheme-based explosives. San Francisco, missing Nick Bosa and other pieces, ranks near the bottom in turning pressure into sacks. That sets up time for deep and intermediate shots.
San Francisco can answer with Christian McCaffrey and a line that protects. The 49ers own a top-tier third-down conversion rate and an elite sack rate allowed. If they stay on schedule, long drives are in play. Red-zone execution may decide it, since the Bucs’ defense has allowed a high rate of touchdowns inside the 20.
Current Season Form
TB
AwaySF
HomeHead-to-Head Summary
Past Results
| Date | Opponent | Result | ATS | O/U |
|---|---|---|---|---|
| 2025-10-05 | @ SEA | W 38-35 | L 3.5 | o44.5 |
| 2025-09-28 | vs PHI | L 25-31 | L -3.5 | o44.5 |
| 2025-09-21 | vs NYJ | W 29-27 | W +6.5 | o43.5 |
| 2025-09-15 | @ HOU | W 20-19 | L 2.5 | u42.5 |
| 2025-09-07 | @ ATL | W 23-20 | W +-1.5 | u47.5 |
| 2025-01-12 | vs WAS | L 20-23 | P 3.0 | u51.5 |
| 2025-01-05 | vs NO | W 27-19 | W +14.5 | o44.5 |
| 2024-12-29 | vs CAR | W 48-14 | W +9.5 | o47.5 |
| 2024-12-22 | @ DAL | L 24-26 | W +-4.5 | o47.5 |
| 2024-12-15 | @ LAC | W 40-17 | W +3.0 | o46.0 |
Key Insights
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Tampa Bay creates big pass plays (8.4% explosive pass rate, 72nd percentile), while San Francisco allows a high rate of explosive passes (8.7%, 19th percentile).
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The 49ers’ pass protection is elite (2.4% sack rate allowed, 94th percentile), which can offset Tampa Bay’s average pressure-to-sack conversion (5.3%, 44th percentile).
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San Francisco is strong on third down (45.7% conversion, 88th percentile) and on third-and-long (35.7%, 94th percentile), helping sustain drives.
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Tampa Bay is efficient on long drives (93.8%, 89th percentile) and stops short-yardage at the goal line (66.7% stuff rate, 84th percentile), but its red-zone TD defense has struggled (71.4% allowed, 11th percentile).
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Injuries shape the pass game: TB is without Mike Evans, and Chris Godwin is questionable; SF is without Brandon Aiyuk and George Kittle, with multiple WRs and DBs questionable. Tie this to volatility on perimeter matchups.
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San Francisco’s pass rush ranks low in pressure-to-sack and sack rate generated (both 3rd percentile), which can give Tampa’s QB time even with OL questions.
Betting Insights
Anchor spread: Buccaneers -3.5 (+114). Plus money to cover the hook at home, tied to TB’s explosive pass edge. Price brings added risk.
Alternate/key number: Buccaneers -3.0 (-103). Near even-money tax if you prefer protection against a field-goal game.
Anchor total: 47.0 (Over -116 / Under -110). Both offenses carry efficiency traits; Over backers are paying a bit of juice.
Emeka Egbuka Over 68.5 receiving yards (-122). Fits TB’s explosive pass and scheme-explosive traits against SF’s leaky deep-pass profile.
Baker Mayfield Over 240.5 passing yards (-119). SF converts pressure to sacks just 2.3% of the time; cleaner pockets support yardage. Status note: Mayfield QUESTIONABLE.
Chris Godwin Over 51.5 receiving yards (-119). Volume should rise without Evans. Status note: Godwin QUESTIONABLE, so expect line movement if inactive.
Christian McCaffrey Over 49.5 receiving yards (-118). SF’s third-down strength and TB’s red-zone issues often funnel targets to CMC.
Final Summary
On paper, Tampa’s passing explosiveness lines up well against a San Francisco defense that hasn’t finished pressures. If Baker Mayfield plays, the Bucs should find chunk gains to Emeka Egbuka and the tight ends, with drives extending into scoring range.
San Francisco can keep pace by keeping Mac Jones clean and using Christian McCaffrey as a receiver. The 49ers have been excellent on third down and on sustained drives. If they finish in the red zone, this tilts toward a shootout around our anchor total.
Given the injuries, expect volatility. Questionable tags on both quarterbacks and multiple pass catchers can swing props and side totals close to kickoff. Price matters: the -3.5 at plus money on Tampa is a higher-variance angle, while -3.0 reduces the sweat.
Our lean: Tampa Bay to cover the small number at home and a game that nudges into the high 40s. Play responsibly, respect the juice, and be ready to adjust if late inactives hit the receiving rooms.
Statistical Battle Boards
OffenseDefense| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Total Points | 106 | #19 | 132 | #9 | |
| Total Points Per Game | 21.2 | #22 | 26.4 | #23 | |
| Total Touchdowns | 10 | #24 | 16 | #29 | |
| Passing Touchdowns | 10 | #4 | 10 | #26 | |
| Rushing Touchdowns | 0 | #32 | 4 | #19 | |
| Other Touchdowns | 0 | #23 | 2 | #30 | |
| Total Kicking Points | 44 | #5 | 36 | #16 | |
| Total Two Point Conversions | 1 | #9 | 0 | #19 | |
| Kick Extra Points | 8 | #25 | 15 | #5 | |
OffenseDefense| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Net Passing Yards | 1453 | #1 | 1092 | #12 | |
| Net Passing Yards Per Game | 291 | #1 | 218 | #13 | |
| Passer Rating | 94.3 | #18 | 105 | #6 | |
| Passing Attempts | 202 | #1 | 160 | #19 | |
| Completions | 134 | #2 | 109 | #13 | |
| Completion Percentage | 66.3 | #17 | 68.1 | #22 | |
| Passing 1st downs | 80 | #1 | 64 | #27 | |
| Passing 1st Down % | 69.6 | #2 | 64.6 | #30 | |
| Longest Pass | 45 | #29 | 53 | #15 | |
| Passing Fumbles Lost | 3 | #1 | 1 | #14 | |
| Receiving Targets | 195 | #2 | 158 | #13 | |
| Receptions | 134 | #2 | 109 | #20 | |
| Receiving Yards After Catch | 674 | #2 | 605 | #27 | |
| YAC Average | 5.0 | #17 | 5.6 | #27 | |
OffenseDefense| Statistic | Offense | Rank | Defense | Rank | Advantage |
|---|---|---|---|---|---|
| Rushing Yards | 426 | #27 | 462 | #10 | |
| Rushing Yards Per Game | 85.2 | #28 | 92.4 | #24 | |
| Rushing Attempts | 139 | #10 | 122 | #13 | |
| Yards Per Rush Attempt | 3.1 | #31 | 3.8 | #27 | |
| Rushing 1st downs | 25 | #29 | 23 | #5 | |
| 20+ Yard Rushing Plays | 0 | #29 | 4 | #9 | |
| Long Rushing | 19 | #29 | 31 | #21 | |
| Rushing Fumbles | 0 | #29 | 4 | #9 | |
| Rushing Fumbles Lost | 0 | #18 | 0 | #30 | |
Game Preview of San Francisco 49ers @ Tampa Bay Buccaneers. Week 6 of 2025 NFL Season
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