NFL Monday Night Football Week 2 Predictions: Bills vs Titans Prediction & Vikings vs Eagles Prediction

In a Week 2 Monday night doubleheader, the Bills and Eagles return home seeking 2-0 starts against star-studded competition.

Monday Night Football Week 2 Predictions Recommended Bets: 

Bills vs Titans Prediction and Game Preview

The first game of Monday’s NFL doubleheader features a matchup between Week 1’s most impressive team and arguably its most disappointing. The Bills were dominant against the reigning Super Bowl champion Rams, whereas the Titans let multiple leads slip away in a dramatic 21-20 home loss to the Giants. As far as Bills vs Titans predictions are concerned, Buffalo is a 10-point home favorite on Monday night. Josh Allen & co are looking to avenge a 34-31 Monday night loss in Nashville last season, in which there were seven lead changes. The over/under for Monday’s game is listed at 49.5 points, suggesting another shootout may be on the cards.

The Bills were incredibly impressive for a team that committed four turnovers last week. Josh Allen’s two interceptions were more the fault of his receivers than his own. However, fumbles by both Zack Moss and James Cook are a bit more concerning. The fact that Allen was the team’s leading rusher could also be a bad omen for the offense. Nevertheless, Allen connected on 26 of his 29 passes that weren’t intercepted for 297 yards. The Bills also had four players with at least three catches, with Stefon Diggs and Gabe Davis leading the way with a combined 210 receiving yards. In Week 2, the Bills’ offense faces a Tennessee secondary that’s even more talented than the Rams. The Titans were shredded on the ground last week, as the Giants racked up 238 rushing yards on 7.4 yards per carry.

The Titans, meanwhile, had plenty of shortcomings in Week 1. Star running back Derrick Henry was limited to just 82 yards on 21 carries, which isn’t enough from the team’s offensive engine. Also, outside of two touchdown passes to Dontrell Hilliard, quarterback Ryan Tannehill simply couldn’t pick up the slack, spreading the ball around to a fault, as evidenced by two Tennessee receivers, rookies Kyle Philips and Treylon Burks, seeing at least five targets. If that continues to be the case, this passing game will experience some severe growing pains. 

It gets no easier for the Titans in Week 2 against a Buffalo defense that tallied seven sacks in Week 1. Future Hall of Famer Von Miller had two of those sacks, looking like a disruptive force on a defense that was one of the best in the NFL last season without him.

While it’s not easy to cover 10 points in the NFL, it’s our Bills vs Titans prediction that they have a great chance to do that on Monday. If Buffalo’s defense can come close to containing Henry like they did the Rams’ running game (which they limited to 52 yards on 18 carries), the burden will be on Tannehill, who will likely struggle to come up with answers. That should allow Allen and the Buffalo offense plenty of time to run up the score and cover the spread.

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Vikings vs Eagles Prediction and Game Preview

There could be some offensive fireworks in the second half of Monday’s doubleheader as the Eagles host the Vikings. Both teams were victorious in Week 1, giving each side a chance to get off to a 2-0 start. With the Eagles favored at home by just 2.5 points, this should be a close and competitive game and thus make Vikings vs Eagles predictions tougher. The best Vikings vs Eagles prediction on the board is for a high-scoring game in which the teams blow past the over/under line of 51.5 points.

Philly’s offense was undoubtedly humming in Week 1, though, oddly, the Eagles didn’t score in the fourth quarter of their shootout win over the Lions but still managed a 38-35 win. The offense got some help from a pick-six by the defense, but the Eagles looked balanced offensively, getting 243 passing yards from Jalen Hurts and 216 rushing yards, 90 of which came from Hurts. On the other hand, Minnesota’s defense put on a clinic against the Packers, forcing an interception and a fumble by Aaron Rodgers and severely limiting the effectiveness of Green Bay’s wide receivers.

Meanwhile, the Vikings got a superstar performance from wide receiver Justin Jefferson, who had nine catches for 184 yards and two touchdowns. Minnesota didn’t need much else, although Dalvin Cook and Alexander Mattison combined for 126 rushing yards on the ground (on 4.5 yards per carry) to balance out the Vikings’ attack. The Vikings are now facing a talented Philadelphia defense that looked vulnerable last week, particularly against the run, in giving up 35 points to the Lions. 

On their home field in Week 2, the Eagles’ defense should improve a fair bit. They’ll be focused on preventing Jefferson from hurting them the way he did Green Bay last week. At the same time, Philadelphia’s balance on offense will prevent the Vikings from dominating defensively as they did a week ago. It’s worth noting that fantastic performance came against a Packers receiving corps that did not pose a legitimate threat at any point. They won’t enjoy that luxury this week against the Eagles’ duo of A.J. Brown and Devonta Smith. Balance on offense and the home crowd behind them will be the difference on Monday, allowing the Eagles to win and cover.

Vikings vs Eagles Prediction - Recommended Bets: 


Monday Night Football brings us some great games our MNF Predictions focus on the Bills vs Titans and the Eagles vs Vikings. Interested in more football content? Be sure to read our guide: How To Bet on American Football or take a look at some of the best Football betting promos available. Visit our odds comparison tool to compare the latest odds. 


Frequently Asked Questions (FAQs)

Who is favored to win in the Eagles vs Vikings game?

The Eagles are favored by 2.5 points at home against the Vikings for Monday’s game, although that line could change in the lead-up to the game.

Where will the Eagles vs Vikings game take place?

The Eagles are hosting the Vikings and so the game will be played at Lincoln Financial Field in Philadelphia.

Who is favored to win in the Bills vs Titans?

The Bills are currently favored by 10 points at home against the Titans, although that line could change in the lead-up to the game.


Written by Bryan Zarpentine.

Bryan has been a sports and sports betting writer for over 12 years. When he's not writing about sports, he's usually watching sports, attending sporting events, or on road trips on his way to sporting events.  

Bryan is an NCAA football and basketball specialist who gives excellent insight into MLB and the NFL worlds.