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MLB Picks Today: Ace Pitching Defines Tuesday's Slate - April 21

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Tuesday's 15-game slate is pitcher-driven. Imanaga's 12.68 K/9 and six-day repeat matchup against a Phillies lineup vulnerable to left-handed pitching anchor the headline. Chapman's 0-for-12 career shutout against Yamamoto at Oracle Park reinforces the thesis: when apex pitching aligns with context, the value compounds.

Today's Best Bets

Los Angeles Dodgers @ San Francisco Giants , Matt Chapman under 0.5 hits
Props
Matt Chapman under 0.5 hits+128

Matt Chapman Under 0.5 Hits (+128): This is the cleanest edge on the board. Chapman is 0-for-12 against Yamamoto in 12 career plate appearances with a .250 OPS. The 2025 sample alone covers 9 PA at a .222 OPS. He is batting .292 this season and is a quality hitter against right-handers broadly, which is exactly why the market is still offering plus money at +128, implying 43.9%. The BvP record is not marginal. It is categorical. Zero hits in a sample large enough to mean something, at positive odds, is rare structural value. This is the sharpest individual prop on tonight's slate.

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Philadelphia Phillies @ Chicago Cubs , Shota Imanaga over 6.5 strikeouts
Props
Shota Imanaga over 6.5 strikeouts-122

Shota Imanaga Over 6.5 Strikeouts (-122, HIGH): This is the strongest pick on the board. His last start against this Phillies lineup produced 11 strikeouts in 6 innings. The start before that: 9 strikeouts. He is posting a 12.68 K/9 in 2026 with a 2.17 FIP that confirms the underlying stuff is real. Philadelphia allows 10.06 K/9 as a team and is 2-8 against left-handed pitching. Harper, Schwarber, Marsh, and Realmuto are all 0-for their 2026 plate appearances against him with no extra-base hits. The 6.5 line is conservatively set given the matchup. Lead bet tonight.

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Philadelphia Phillies @ Chicago Cubs , Chicago Cubs -1.5
run_line
Chicago Cubs -1.5+144

Cubs -1.5 Run Line (+144, MEDIUM): This is where the structural edge translates into plus-money value. Imanaga's 2.45 ERA and 11-strikeout performance against this exact Phillies lineup six days ago make a multi-run Cubs win the most likely game path. Philadelphia's 2-8 record against left-handed pitching structurally caps their offensive ceiling tonight. The market implies only a 41% probability for Cubs -1.5, which underprices the situational edge when one team is sending out an elite arm against a lineup that cannot hit southpaws. Best value angle in the game.

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Houston Astros @ Cleveland Guardians , Cleveland Guardians -1.5
run_line
Cleveland Guardians -1.5+134

Cleveland Guardians -1.5 (+134, MEDIUM confidence): This is the primary play. Messick's 1.05 ERA against Weiss's 6.75 ERA and 6.1 BB/9 is the biggest documented pitching gap on the board. Cleveland is 7-4 at home and its patient lineup converts free passes into runs without needing to hit the ball hard. The +134 price accounts for Cleveland's 7-10 record against right-handed starters, which is the main risk to fading. That is a fair exchange for a run line supported by this level of pitching mismatch.

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Baltimore Orioles @ Kansas City Royals , Under 9.0
Total
Under 9.0-110

Under 9.0 (-110) | Total | MEDIUM Confidence The structural case here is as clean as you will find on this slate. Baltimore is missing six starters and is hitting .201/.295/.316 on the road. Kansas City scores 3.3 runs per game and is historically bad right now. Bubic has never allowed an earned run against this Baltimore team across three career starts. Even without a perfect outing from either pitcher, the offensive floors on both sides are low enough that reaching nine total runs requires multiple things to go right simultaneously. The -110 price is fair for a game where both offenses are near the bottom of the league in production.

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Atlanta Braves @ Washington Nationals , Atlanta Braves -1.5
run_line
Atlanta Braves -1.5+108

Atlanta Braves -1.5 (+108) , MEDIUM confidence (primary play). Plus money on a six-game winning streak road team, against a starter who has zero career reps against any of their hitters, at a venue where the home team is 2-8. Atlanta is scoring 5.7 runs per game and is 6-1 against left-handed pitching this season. Washington's bullpen is the 25th-ranked relief unit in baseball. The market has Atlanta at -154 on the moneyline but is offering +108 on the run line. That gap is where the value lives tonight. Griffin typically exits before the sixth inning, at which point Atlanta's lineup rolls through a struggling bullpen for multiple frames. This is the clearest play on the board.

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Full Slate

★★★High★★Medium★★Low
PropsBen Rice 0.5
run_lineBoston Red Sox +1.5
PropsLuis Gil 4.5
PropsConnelly Early 5.5
PropsTrevor Story 0.5
PropsAaron Judge None
TotalUnder 8.5
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PropsYordan Alvarez None
run_lineCleveland Guardians -1.5
PropsParker Messick 5.5
PropsYainer Diaz 0.5
PropsJosé Ramírez 1.5
TotalUnder 8.5
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PropsDustin May 4.5
PropsChris Paddack 4.5
PropsJordan Walker None
PropsJakob Marsee 0.5
PropsXavier Edwards 0.5
run_lineSt. Louis Cardinals +1.5
TotalOver 8.5
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PropsSimeon Woods Richardson 4.5
run_lineNew York Mets -1.0
PropsNolan McLean 6.5
PropsLuis Robert Jr. 0.5
PropsMJ Melendez 0.5
TotalUnder 7.5
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PropsFrancisco Alvarez 0.5
PropsShota Imanaga 6.5
PropsJesús Luzardo 6.5
run_lineChicago Cubs -1.5
PropsNico Hoerner 1.5
PropsKyle Schwarber 0.5
TotalUnder 8.0
ML
PropsAlex Bregman None
PropsMatt Chapman 0.5
run_lineSan Francisco Giants +1.5
PropsLanden Roupp 4.5
PropsYoshinobu Yamamoto 5.5
PropsRafael Devers 0.5
PropsAndy Pages 1.5
TotalUnder 7.0
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run_lineAtlanta Braves -1.5
PropsReynaldo López 4.5
PropsMatt Olson 1.5
PropsAustin Riley None
TotalOver 8.5
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PropsJacob Young 0.5
PropsDrake Baldwin 0.5
run_lineCincinnati Reds -1.0
MLCincinnati Reds
PropsChase Burns 5.5
PropsSteven Matz 5.5
PropsEugenio Suárez 0.5
PropsKe'Bryan Hayes 0.5
PropsSal Stewart 1.5
TotalUnder 7.5
PropsKeider Montero 3.5
PropsGleyber Torres 0.5
PropsDillon Dingler 0.5
PropsGary Sánchez 0.5
PropsJoey Ortiz 0.5
run_lineDetroit Tigers -1.5
TotalUnder 8.5
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run_lineBaltimore Orioles +1.5
TotalUnder 9.0
PropsKris Bubic 6.5
PropsTaylor Ward 1.5
PropsGunnar Henderson 0.5
PropsVinnie Pasquantino 0.5
ML
PropsShane Baz 4.5
Pittsburgh Pirates at Texas Rangers
PropsCarmen Mlodzinski 4.5
PropsKumar Rocker 5.5
PropsMarcell Ozuna 0.5
PropsRyan O'Hearn 0.5
run_linePittsburgh Pirates -1.5
TotalUnder 8.5
MLPittsburgh Pirates
PropsBrandon Lowe None
run_lineSeattle Mariners -1.0
PropsJacob Lopez 5.5
PropsJeff McNeil 0.5
PropsJacob Wilson 0.5
PropsRandy Arozarena 0.5
TotalUnder 7.5
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PropsShea Langeliers None
run_lineChicago White Sox +1.5
PropsMerrill Kelly 4.5
PropsMunetaka Murakami None
PropsCorbin Carroll 1.5
PropsSean Burke 4.5
TotalOver 8.5
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PropsKetel Marte 0.5
San Diego Padres at Colorado Rockies
PropsRandy Vásquez 4.5
PropsEzequiel Tovar 1.5
PropsMickey Moniak None
run_lineSan Diego Padres -1.5
TotalOver 11.0
ML
PropsKyle Karros 0.5
run_lineToronto Blue Jays -1.0
TotalUnder 9.5
ML

Matt Chapman under 0.5 hits at +128 is the sharpest edge on the board, with Oracle Park's run factor compounding his 0-for-12 career shutout against Yamamoto. Pair this with the Cubs and Guardians spreads to capture the full slate narrative. All picks are for informational purposes only. Please gamble responsibly.